Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins.
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چکیده
منابع مشابه
Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins.
Leukocyte accumulation in cerebrospinal fluid and disruption of the blood-brain barrier are central components of meningitis and are associated with a poor prognosis. Genetically engineered deficiencies or functional inhibition of endothelial leukocyte adhesion receptors P-, or P- plus E-selectins, lead to deficits in leukocyte rolling and extravasation. However, their impact on meningeal infla...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1996
ISSN: 0021-9738
DOI: 10.1172/jci118695